Basic Sciences - (Recent Publications 2017)

Ibán-Arias R, Lisa S, Mastrodimou N, Kokona D, Koulakis E, Iordanidou P, Kouvarakis A, Fothiadaki M, Papadogkonaki S, Sotiriou A, Katerinopoulos HE, Gravanis A, Charalampopoulos I, Thermos K. The Synthetic Microneurotrophin BNN27 Affects Retinal Function in Rats With Streptozotocin-Induced Diabetes. Diabetes. 2018 Feb;67(2):321-333. doi: 10.2337/db17-0391. Epub 2017 Dec 5. PubMed PMID: 29208634.
Liapakis G. Editorial: Corticotropin Releasing Factor (CRF) and its Receptors: From Structure to Function in Health and Disease (Part I). Curr Mol Pharmacol. 2017;10(4):257-258. doi: 10.2174/187446721004171004092955. PubMed PMID: 29025388.
Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T. DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway. Mol Psychiatry. 2018 Jun;23(6):1410-1420. doi: 10.1038/mp.2017.167. Epub 2017 Sep 12. PubMed PMID: 28894299.
Teleb M, Kuppast B, Spyridaki K, Liapakis G, Fahmy H. Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists. Eur J Med Chem. 2017 Sep 29;138:900-908. doi: 10.1016/j.ejmech.2017.07.016. Epub 2017 Jul 18. PubMed PMID: 28750312.
Bonetto G, Charalampopoulos I, Gravanis A, Karagogeos D. The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone-induced death, through the NGF receptor TrkA. Glia. 2017 Aug;65(8):1376-1394. doi: 10.1002/glia.23170. Epub 2017 Jun 1. PubMed PMID: 28567989.
Botsakis K, Mourtzi T, Panagiotakopoulou V, Vreka M, Stathopoulos GT, Pediaditakis I, Charalampopoulos I, Gravanis A, Delis F, Antoniou K, Zisimopoulos D, Georgiou CD, Panagopoulos NT, Matsokis N, Angelatou F. BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor. Neuropharmacology. 2017 Jul 15;121:140-157. doi: 10.1016/j.neuropharm.2017.04.043. Epub 2017 Apr 28. PubMed PMID: 28461162.
Pitsikas N, Gravanis A. The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats. Neurobiol Learn Mem. 2017 Apr;140:145-153. doi: 10.1016/j.nlm.2017.03.004. Epub 2017 Mar 6. PubMed PMID: 28274826.
Liapakis G, Matsoukas MT, Karageorgos V, Venihaki M, Mavromoustakos T. Family B G Protein-coupled Receptors and their Ligands: From Structure to Function. Curr Med Chem. 2017;24(31):3323-3355. doi: 10.2174/0929867324666170303162416. Review. PubMed PMID: 28266266.
Cordomi A, Liapakis G, Matsoukas MT. Understanding Corticotropin Releasing Factor Receptor (CRFR) Activation Using Structural Models. Curr Mol Pharmacol. 2017;10(4):325-333. doi: 10.2174/1874467210666170110122939. Review. PubMed PMID: 28103783.
Gravanis A, Pediaditakis I, Charalampopoulos I. Synthetic microneurotrophins in therapeutics of neurodegeneration. Oncotarget. 2017 Feb 7;8(6):9005-9006. doi: 10.18632/oncotarget.14667. PubMed PMID: 28099949; PubMed Central PMCID: PMC5354705.
Paneri S, Gregoriou GG. Top-Down Control of Visual Attention by the Prefrontal Cortex. Functional Specialization and Long-Range Interactions. Front Neurosci. 2017 Sep 29;11:545. doi: 10.3389/fnins.2017.00545. eCollection 2017. Review. PubMed PMID: 29033784; PubMed Central PMCID: PMC5626849.
Papadourakis V, Raos V. Evidence for the representation of movement kinematics in the discharge of F5 mirror neurons during the observation of transitive and intransitive actions. J Neurophysiol. 2017 Dec 1;118(6):3215-3229. doi: 10.1152/jn.00816.2016. Epub 2017 Sep 20. PubMed PMID: 28931615.
Neromyliotis E, Moschovakis AK. Saccades evoked in response to electrical stimulation of the posterior bank of the arcuate sulcus. Exp Brain Res. 2017 Sep;235(9):2797-2809. doi: 10.1007/s00221-017-5012-6. Epub 2017 Jun 20. PubMed PMID: 28634888.
Neromyliotis E, Moschovakis AK. Response Properties of Motor Equivalence Neurons of the Primate Premotor Cortex. Front Behav Neurosci. 2017 Apr 12;11:61. doi: 10.3389/fnbeh.2017.00061. eCollection 2017. PubMed PMID: 28446867; PubMed Central PMCID: PMC5388740.
Simos PG, Kavroulakis E, Maris T, Papadaki E, Boursianis T, Kalaitzakis G, Savaki HE. Neural foundations of overt and covert actions. Neuroimage. 2017 May 15;152:482-496. doi: 10.1016/j.neuroimage.2017.03.036. Epub 2017 Mar 18. PubMed PMID: 28323166.
Raos V, Savaki HE. The Role of the Prefrontal Cortex in Action Perception. Cereb Cortex. 2017 Oct 1;27(10):4677-4690. doi: 10.1093/cercor/bhw261. PubMed PMID: 27600843.
Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. J Vis Exp. 2017 Nov 22;(129). doi: 10.3791/56301. PubMed PMID: 29286376; PubMed Central PMCID: PMC5755444.
Ramnarayan P, Intikhab Z, Spenceley N, Iliopoulos I, Duff A, Millar J. Inter-hospital transport of the child with critical cardiac disease. Cardiol Young. 2017 Dec;27(S6):S40-S46. doi: 10.1017/S1047951117002608. Review. PubMed PMID: 29198261.
Rieckher M, Tavernarakis N. Caenorhabditis elegans Microinjection. Bio Protoc. 2017 Oct 5;7(19). pii: e2565. doi: 10.21769/BioProtoc.2565. PubMed PMID: 29071286; PubMed Central PMCID: PMC5734614.
Pavlopoulos GA, Paez-Espino D, Kyrpides NC, Iliopoulos I. Empirical Comparison of Visualization Tools for Larger-Scale Network Analysis. Adv Bioinformatics. 2017;2017:1278932. doi: 10.1155/2017/1278932. Epub 2017 Jul 18. Review. PubMed PMID: 28804499; PubMed Central PMCID: PMC5540468.
Nikoletopoulou V, Tavernarakis N. The PMR1 pump in alpha-synuclein toxicity and neurodegeneration. Neurosci Lett. 2018 Jan 10;663:66-71. doi: 10.1016/j.neulet.2017.08.006. Epub 2017 Aug 2. Review. PubMed PMID: 28780169.
Theodosiou T, Efstathiou G, Papanikolaou N, Kyrpides NC, Bagos PG, Iliopoulos I, Pavlopoulos GA. NAP: The Network Analysis Profiler, a web tool for easier topological analysis and comparison of medium-scale biological networks. BMC Res Notes. 2017 Jul 14;10(1):278. doi: 10.1186/s13104-017-2607-8. PubMed PMID: 28705239; PubMed Central PMCID: PMC5513407.
Kyriakakis E, Charmpilas N, Tavernarakis N. Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans. Sci Rep. 2017 Jul 11;7(1):5115. doi: 10.1038/s41598-017-05276-2. PubMed PMID: 28698593; PubMed Central PMCID: PMC5505976.
Nikoletopoulou V, Sidiropoulou K, Kallergi E, Dalezios Y, Tavernarakis N. Modulation of Autophagy by BDNF Underlies Synaptic Plasticity. Cell Metab. 2017 Jul 5;26(1):230-242.e5. doi: 10.1016/j.cmet.2017.06.005. PubMed PMID: 28683289.
Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review. PubMed PMID: 28596378; PubMed Central PMCID: PMC5494474.
Bonetto G, Charalampopoulos I, Gravanis A, Karagogeos D. The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone-induced death, through the NGF receptor TrkA. Glia. 2017 Aug;65(8):1376-1394. doi: 10.1002/glia.23170. Epub 2017 Jun 1. PubMed PMID: 28567989.
Pinatel D, Hivert B, Saint-Martin M, Noraz N, Savvaki M, Karagogeos D, Faivre-Sarrailh C. The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons. J Cell Sci. 2017 Jul 1;130(13):2209-2220. doi: 10.1242/jcs.202267. Epub 2017 May 22. PubMed PMID: 28533267.
Efstathiou G, Antonakis AN, Pavlopoulos GA, Theodosiou T, Divanach P, Trudgian DC, Thomas B, Papanikolaou N, Aivaliotis M, Acuto O, Iliopoulos I. ProteoSign: an end-user online differential proteomics statistical analysis platform. Nucleic Acids Res. 2017 Jul 3;45(W1):W300-W306. doi: 10.1093/nar/gkx444. PubMed PMID: 28520987; PubMed Central PMCID: PMC5793730.
Palikaras K, Daskalaki I, Markaki M, Tavernarakis N. Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover. Pharmacol Ther. 2017 Oct;178:157-174. doi: 10.1016/j.pharmthera.2017.04.005. Epub 2017 Apr 29. Review. PubMed PMID: 28461251.
Ntourantonis D, Panagopoulos A, Iliopoulos I, Tatani I, Tsoumpos P, Kouzelis A, Tyllianakis M. Translation, cultural adaptation, validity and reliability of the Greek version of the modified Constant Score. JSES Open Access. 2017 Apr 19;1(1):45-50. doi: 10.1016/j.jses.2017.02.004. eCollection 2017 Mar. PubMed PMID: 30675539; PubMed Central PMCID: PMC6340836.
Palikaras K, Tavernarakis N. In vivo Mitophagy Monitoring in Caenorhabditis elegans to Determine Mitochondrial Homeostasis. Bio Protoc. 2017 Apr 5;7(7). pii: e2215. doi: 10.21769/BioProtoc.2215. PubMed PMID: 28405595; PubMed Central PMCID: PMC5386141.
Kourtis N, Tavernarakis N. Protein Synthesis Rate Assessment by Fluorescence Recovery after Photobleaching (FRAP). Bio Protoc. 2017 Mar 5;7(5). pii: e2156. doi: 10.21769/BioProtoc.2156. PubMed PMID: 28286807; PubMed Central PMCID: PMC5344182.
Palikaras K, Tavernarakis N. Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis elegans. Methods Mol Biol. 2017;1567:349-361. doi: 10.1007/978-1-4939-6824-4_21. PubMed PMID: 28276029.
Rieckher M, Tavernarakis N. P-body and Stress Granule Quantification in Caenorhabditis elegans. Bio Protoc. 2017 Jan 20;7(2). pii: e2018. doi: 10.21769/BioProtoc.2108. PubMed PMID: 28239624; PubMed Central PMCID: PMC5321477.
Princz A, Tavernarakis N. The role of SUMOylation in ageing and senescent decline. Mech Ageing Dev. 2017 Mar;162:85-90. doi: 10.1016/j.mad.2017.01.002. Epub 2017 Jan 11. Review. PubMed PMID: 28088449.
Charmpilas N, Kyriakakis E, Tavernarakis N. Small heat shock proteins in ageing and age-related diseases. Cell Stress Chaperones. 2017 Jul;22(4):481-492. doi: 10.1007/s12192-016-0761-x. Epub 2017 Jan 10. Review. PubMed PMID: 28074336; PubMed Central PMCID: PMC5465026.
Papandreou ME, Tavernarakis N. Autophagy and the endo/exosomal pathways in health and disease. Biotechnol J. 2017 Jan;12(1). doi: 10.1002/biot.201600175. Epub 2016 Dec 15. Review. PubMed PMID: 27976834.
Palikaras K, Mari M, Petanidou B, Pasparaki A, Filippidis G, Tavernarakis N. Ectopic fat deposition contributes to age-associated pathology in Caenorhabditis elegans. J Lipid Res. 2017 Jan;58(1):72-80. doi: 10.1194/jlr.M069385. Epub 2016 Nov 24. PubMed PMID: 27884963; PubMed Central PMCID: PMC5234711.
Ploumi C, Daskalaki I, Tavernarakis N. Mitochondrial biogenesis and clearance: a balancing act. FEBS J. 2017 Jan;284(2):183-195. doi: 10.1111/febs.13820. Epub 2016 Aug 11. Review. PubMed PMID: 27462821.
Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A. Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma. Cell Death Differ. 2018 May;25(5):885-903. doi: 10.1038/s41418-017-0021-3. Epub 2017 Dec 11. PubMed PMID: 29230000; PubMed Central PMCID: PMC5943406.
Lang F, Pelzl L, Schöls L, Hermann A, Föller M, Schäffer TE, Stournaras C. Neurons, Erythrocytes and Beyond -The Diverse Functions of Chorein. Neurosignals. 2017;25(1):117-126. doi: 10.1159/000485457. Epub 2017 Nov 28. Review. PubMed PMID: 29179176.
Pelzl L, Elsir B, Sahu I, Bissinger R, Singh Y, Sukkar B, Honisch S, Schoels L, Jemaà M, Lang E, Storch A, Hermann A, Stournaras C, Lang F. Lithium Sensitivity of Store Operated Ca2+ Entry and Survival of Fibroblasts Isolated from Chorea-Acanthocytosis Patients. Cell PhysiolBiochem. 2017;42(5):2066-2077. doi: 10.1159/000479901. Epub 2017 Aug 11. PubMed PMID: 28803243.
Pelzl L, Hauser S, Elsir B, Sukkar B, Sahu I, Singh Y, Höflinger P, Bissinger R, Jemaà M, Stournaras C, Schöls L, Lang F. Lithium Sensitive ORAI1 Expression, Store Operated Ca(2+) Entry and Suicidal Death of Neurons in Chorea-Acanthocytosis. Sci Rep. 2017 Jul 25;7(1):6457. doi: 10.1038/s41598-017-06451-1. PubMed PMID: 28743945; PubMed Central PMCID: PMC5526875.
Nomikou E, Stournaras C, Kardassis D. Functional analysis of the promoters of the small GTPasesRhoA and RhoB in embryonic stem cells. BiochemBiophys Res Commun. 2017 Sep 23;491(3):754-759. doi: 10.1016/j.bbrc.2017.07.114. Epub 2017 Jul 21. PubMed PMID: 28739254.
Stagno MJ, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al-Maghout T, Kallergi G, Alkahtani S, Alevizopoulos K, Dimas K, Calogeropoulou T, Warmann SW, Lang F, Schmid E, Stournaras C. Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells. Cell PhysiolBiochem. 2017;42(4):1366-1376. doi: 10.1159/000479200. Epub 2017 Jul 14. PubMed PMID: 28704809.
Peraki I, Palis J, Mavrothalassitis G. The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis. Mol Cell Biol. 2017 Sep 12;37(19). pii: e00183-17. doi: 10.1128/MCB.00183-17. Print 2017 Oct 1. PubMed PMID: 28694332; PubMed Central PMCID: PMC5599724.
Pelzl L, Hosseinzadeh Z, Al-Maghout T, Singh Y, Sahu I, Bissinger R, Schmidt S, Alkahtani S, Stournaras C, Toulany M, Lang F. Role of Na+/Ca2+ Exchangers in Therapy Resistance of Medulloblastoma Cells. Cell PhysiolBiochem. 2017;42(3):1240-1251. doi: 10.1159/000478953. Epub 2017 Jul 3. PubMed PMID: 28683437.
Kanaki M, Tiniakou I, Thymiakou E, Kardassis D. Physical and functional interactions between nuclear receptor LXRα and the forkhead box transcription factor FOXA2 regulate the response of the human lipoprotein lipase gene to oxysterols in hepatic cells. BiochimBiophysActa Gene Regul Mech. 2017 Aug;1860(8):848-860. doi: 10.1016/j.bbagrm.2017.05.007. Epub 2017 May 31. PubMed PMID: 28576574.
Trusca VG, Fuior EV, Fenyo IM, Kardassis D, Simionescu M, Gafencu AV. Differential action of glucocorticoids on apolipoprotein E gene expression in macrophages and hepatocytes. PLoS One. 2017 Mar 29;12(3):e0174078. doi: 10.1371/journal.pone.0174078. eCollection 2017. PubMed PMID: 28355284; PubMed Central PMCID: PMC5371326.
Vorgia E, Zaragkoulias A, Peraki I, Mavrothalassitis G. Suppression of Fgf2 by ETS2 repressor factor (ERF) is required for chorionic trophoblast differentiation. MolReprod Dev. 2017 Apr;84(4):286-295. doi: 10.1002/mrd.22780. Epub 2017 Feb 28. PubMed PMID: 28244611.
Kanaki M, Kardassis D. Regulation of the human lipoprotein lipase gene by the forkhead box transcription factor FOXA2/HNF-3β in hepatic cells. BiochimBiophys Acta Gene Regul Mech. 2017 Mar;1860(3):327-336. doi: 10.1016/j.bbagrm.2017.01.007. Epub 2017 Jan 23. PubMed PMID: 28126606.
Agelaki S, Dragolia M, Markonanolaki H, Alkahtani S, Stournaras C, Georgoulias V, Kallergi G. Phenotypic characterization of circulating tumor cells in triple negative breast cancer patients. Oncotarget. 2017 Jan 17;8(3):5309-5322. doi: 10.18632/oncotarget.14144. PubMed PMID: 28029660; PubMed Central PMCID: PMC5354910.
Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Vlachos GS, Häupl T, Radbruch A, Sidiropoulos P, Doukoumetzidis K, Kardassis D, Niewold TB, Boumpas DT, Goulielmos GN. Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF). J Cell Physiol. 2017 Jun;232(6):1326-1336. doi: 10.1002/jcp.25602. Epub 2016 Dec 20. PubMed PMID: 27636101.
Myrthianou E, Zervou MI, Budu-Aggrey A, Eliopoulos E, Kardassis D, Boumpas DT, Kougkas N, Barton A, Sidiropoulos P, Goulielmos GN. Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population. Scand J Rheumatol. 2017 May;46(3):180-186. doi: 10.1080/03009742.2016.1199734. Epub 2016 Jul 20. PubMed PMID: 27440135.