Division of Mother and Child Health - (Research Activities)

Laboratory of the Pediatric Hematology / Oncology Department

(M. Kalmanti, E. Stiakaki, H. Dimitriou)
Post-graduated students= 11, Lab technicians= 1, Post- doctoral researchers= 1
The research interests of the Research Laboratories of Hemopoietic Stem Cells Transplantation and Tissue Cultures includes: Immunophenotypic characterization of cord blood stem cells and their ex vivo expansion. In vitro hematopoiesis of children with malignant diseases. Qualitative evaluation of stem and progenitors cells (bone marrow or peripheral blood derived) and their in vitro expansion. Gene expression studies of genes involved in the pathogenesis and course of childhood malignancies. Study of the plasticity of Hemopoietic stem cells and the use of bone marrow derived stem cells for tissue repair. The role of spectral imaging in childhood acute lymphoblastic leukemia. In vitro study and expansion of mesenchymal cells. The role of apoptosis in childhood acute leukemia. Detection and study of the role of gene polymorphisms in hematologic malignancies of childhood. Characterization of endothelial cells and study of their role in benign disease as well as childhood malignancies. Study of cardiotoxicity in children with malignant diseases. Study of treatment early and late effects in children and adolescents with neoplastic diseases.


Laboratory of the Pediatric Intensive Care Unit

(G. Briassoulis)
- Website: http://briassoulislab.med.uoc.gr/
The Pediatric Intensive Care Unit clinical research interests are focused on sepsis, trauma, respiratory distress and other stress situations. In particular research projects are dealing with nutrition and immune-nutrition in critically ill children, with energy expenditure measurements and relation to multiple organ failure and inflammatory process, and with the role of heat shock proteins in shock and stress situations. In collaboration with the Clinical Chemistry Lab of the University of Crete PICU expands its research interests on the role of immune-nutrition - especially glutamine - and hormonal and inflammatory indices in animal models, including those which belong to the HPAA and chaperokines, on several physiological stressful situations such as the inflammatory stress and sepsis.