Talks by Prof Nicho Hatsopoulos (from University of Chicago)

Dear colleagues and students,
The Graduate Program in the Brain and Mind Sciences announces that Prof Nicho Hatsopoulos (University of Chicago) will give two talks on motor control and Brain Machine Interfaces at the Medical School of the University of Crete and FORTH as follows:

Friday, November 15, 2019:
Decoding the Mind using Brain Machine Interfaces: Turning Thought into Action.

Location: Seminar Room 1 FORTH, Heraklion, Crete

Time 14.00

Two fundamental challenges in developing brain machine interfaces (BMIs) are: 1) Building a decoder between patterns of brain activity and movement in paralyzed patients who can’t move their limbs and 2) Augmenting BMIs with kinesthetic and tactile feedback. We demonstrate two approaches to solving the first challenge by first showing that visual observation of action can automatically trigger mirror-like responses in primary motor cortex that are similar to the responses that occur during action and can be used to build a decoding algorithm without overt movement. We also demonstrate that amputees can learn an arbitrary mapping between brain activity and movement of a robot after long-term exposure to a BMI. The second challenge is addressed by using cortically-controlled exoskeletal robots to provide naturalistic kinesthetic feedback and by using electrical stimulation in somatosensory cortex to deliver artificial tactile feedback.

Monday, November 18, 2019:

Propagating spatiotemporal patterning in motor cortex required for movement initiation

Location: Graduate Studies Amphitheater (7A), Medical School, University of Crete, Heraklion, Crete
Time 10.00 am

Voluntary movement initiation involves the modulations of large groups of neurons in the primary motor cortex (M1). Yet, similar modulations occur during movement planning when no movement occurs. Here, we show that a sequential spatio-temporal pattern of excitability propagates across M1 prior to the movement initiation in one of two oppositely oriented directions along the rostro-caudal axis. Using spatiotemporal patterns of intracortical microstimulation, we find that reaction time increases significantly when stimulation is delivered against but not with the natural propagation direction suggesting that movement initiation requires a precise recruitment pattern in M1. Functional connections among M1 units emerge at movement onset that are oriented along the same rostro-caudal axis but not during movement planning. Finally, we show that beta amplitude profiles can more accurately decode muscle activity when these patterns conform to the natural propagating patterns. These findings provide the first causal evidence that large-scale, propagating patterns of cortical excitability and activity are behaviorally relevant and may be a necessary component of movement initiation.

Prof Hatsopoulos' short bio
Nicholas G. “Nicho” Hatsopoulos, Ph.D. is currently a Professor at the University of Chicago. Dr. Hatsopoulos was also Chairman of the Computational Neuroscience graduate program from 2008-2015. He is currently running a laboratory with four graduate students, three postdoctoral fellows, and several technicians which is funded in part by the National Institutes of Health. From January 1998 to December 2001, Dr. Hatsopoulos was an Assistant Professor of Research in the Department of Neuroscience at Brown University. Dr. Hatsopoulos completed two postdoctoral research fellowships, one in the Department of Neuroscience at Brown University and the other in the Computational Neuroscience Program at the California Institute of Technology.
Dr. Hatsopoulos completed his B.A. in Physics from Williams College in 1984, his M.S. in Psychology in 1991 and his Ph.D. in Cognitive Science from Brown University in 1992.

In 2001, he co-founded a company, Cyberkinetics Neurotechnology Systems, which took the basic scientific research he and his colleagues conducted to develop neural prosthesis technology to assist people with severe motor disabilities.

His research focuses on the neural basis of motor control and learning. He is investigating what features of motor behavior are encoded and how this information is represented in the collective activity of neuronal ensembles in the motor cortex. He is also interested in how these representations change as motor learning occurs. To answer these questions, the electrical discharge of many motor cortical neurons is simultaneously recorded using multi-electrode arrays and correlated with motor behavior. The encoding properties of individual motor cortical neurons are being studied to determine how these single cell properties relate to higher-order representations involving groups of neurons. The possibility that changes in functional connectivity among neurons may occur during motor learning is also being explored.

If you would like to meet with Prof Hatsopoulos and for questions you may have, contact:

Prof. Maria Papadopouli tel. +30.2810.39.1677,
Assoc. Prof Georgia Gregoriou tel +30.2810.39.4505,